6th
International Conference
Inhibitors
of Protein Kinases
including
Insights into Protein
Kinases
,,,
June
27 - July 1, 2009
Warsaw,
Poland
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KINASES/PHOSPHATASES * PHOSPHORYLATION/
DEPHOSPHORYLATION * SIGNALING PATHWAYS * PHOSPHOPROTEOMICS *
BIOCHEMICAL ASPECTS * STRUCTURAL BIOLOGY * INHIBITOR DESIGN * DRUG TARGETS * CLINICAL ASPECTS
* CHEMOTHERAPY
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ORGANIZERS:
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Institute of
Biochemistry & Biophysics,
Polish Academy of Sciences (PAS), Warsaw
and
CoE
BioExploratorium, Division
of
Biophysics, Institute of
Experimental Physics,
Faculty of
Physics, University of Warsaw
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| CO-ORGANIZERS: |
|
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Interdisciplinary
Centre for
Mathematical and Computational Modelling (ICM), University of Warsaw |
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International
Institute of Molecular
& Cell Biology in Warsaw |
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Institute of
Biocybernetics
and Biomedical Engineering, Polish Academy of Sciences (PAS), Warsaw |
Background
Protein
phosphorylation is the most important pathway for regulation
of protein function in living cells. It is involved in the
switching of cellular activities from one state to another
and, in
this way, regulates gene expression, cellular proliferation, and cell
differentation. It is the major mechanism by which cells respond to
extracellular signals, such as hormones and growth factors, and
controls all
events in the various stages of the cell cycle, as well as the response
of the
cell to environmental and nutritional stresses.
Given the key role of
protein kinases and
phosphatases in signal transduction, it was to be anticipated that this
would
stimulate searches for specific inhibitors. Considerable success has
been
attained with the aid of numerous approaches, both experimental and
theoretical, aided in large part by the results of studies on the
three-dimensional
structures of these enzymes, further supported by molecular
modeling and
structure-based drug design. Such inhibitors are now widely applied as
tools
for more precise delineation of signaling pathways.
Dysfunctions of
protein kinases
(and protein phosphatases) are associated with numerous severe
pathological
states. It is consequently not surprising that the pharmaceutical
and
biotechnology sectors are amongst the most active participants in the
design of
protein kinase inhibitors, primarily with an eye to potential
therapeutic
applications. There are now highly potent and selective inhibitors,
with Ki
values in the nanomolar range, and even lower. A number of these are
presently in clinical use or in preclinical trials.
A novel feature of
the 4th and 5th IPK was
the inclusion of several contributions on the protein kinases of
pathogenic
agents, an as yet emerging, but highly promising, field, both for basic
research, and potential therapeutic applications, most timely in
relation to
current world-wide efforts to control diseases such as malaria.
Apart from its
international
character, participants in previous IPK Conferences have included
leading
specialists representing a broad range of disciplines from both
Academia and
the Biotechnology sector, thus ensuring adequate interplay and
stimulating
discussions between those engaged in basic research and representatives
of
biotechnology firms.
The interest shown
by participants
at previous Conferences has encouraged us to undertake organization of
the 6th
IPK, to be held again in Warsaw,
June 27 – July 1, 2009.
In addition to
invited
lectures, there will be several poster sessions. Abstracts of
invited lectures and of posters
accepted for presentation will be published in a special number
of the
international journal Acta Biochimica Polonica, which is
available on
line, amongst others, on MEDLINE. Some posters may be selected for
short oral
presentation.
For purposes
of orientation
as to subject matter, prospective participants may consult the
published
lectures of the five previous IPK Conferences, as follows:
IPK'1998:
Pharmacology & Therapeutics 82 (Nos. 2-3), 1999
IPK'2001: Pharmacology & Therapeutics 99
(Nos.
2-3), 2002
IPK'2003: Biochimica Biophysica
Acta (Proteins &
Proteomics) 1697 (Nos. 1-2), 2004
IPK’2005: Biochimica Biophysica Acta (Proteins &
Proteomics) 1754
(Nos. 1-2), 2005
IPK’2007: Biochimica Biophysica Acta
(Proteins & Proteomics) 1784
(No.1), 2008
We
extend a cordial invitation to participate in the 6th IPK !
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